Role of the prostaglandin E2 EP1 receptor in traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6 wild-type and EP1 receptor knockoutMalen = 6 to 9 per group for lesion and oedema; 6 to 8 and 6 to 7 p…Subcutaneous100 micrograms/kg (a lower dose of 20 micrograms/kg was ini…First injection immediately after controlled cortical impact, second at 24 hour…
Model: Controlled cortical impact traumatic brain injury
Neither post-treatment with SC-51089 nor genetic deletion of the EP1 receptor significantly altered cortical lesion volume, hippocampal swelling or neurological deficit scores at 24 and 48 hours, and injury-induced Iba1 and GFAP increases were unaffected.
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