Delta(9) Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells.

Delta(9) Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells.

Model: Dual intranasal and intraperitoneal Staphylococcal enterotoxin B administration causing inflammatory lung injury and toxic shock

Staphylococcal enterotoxin B exposure caused acute mortality whereas THC treatment led to 100% survival, and THC inhibited the individual microRNAs of the miR-17-92 cluster, reversing enterotoxin-driven suppression of regulatory T cells.

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