Carvedilol promotes neurological function, reduces bone loss and attenuates cell damage after acute spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleOral gavage10 mg/kgAfter spinal cord injury
Model: Acute spinal cord injury
Carvedilol significantly improved locomotor activity, increased tibial bone mineral density through altered RANKL and osteoprotegerin expression, reduced neural damage and astrocyte activation, lowered inflammatory cytokines and oxidative stress, and decreased Fas, Fas ligand, cleaved caspase 3 and…
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