Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.
MouseChemical/toxinC57BL/6MaleAlso administered 4 hours after concanavalin A or acetaminophen injection
Model: Concanavalin A induced immune-mediated hepatitis and acetaminophen induced hepatotoxicity
SH-Man-HSA significantly improved survival in concanavalin A treated mice and was hepatoprotective by suppressing reactive oxygen species production rather than reducing TNF or interferon gamma, outperforming N-acetylcysteine including when given 4 hours after injury.
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