Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.
RatRadiationAthymic nude ratIntrahippocampal (cranial) transplantationGrafted at 2 days, 2 weeks or 4 weeks after irradiation
Model: Acute head-only cranial irradiation at 10 Gy causing cognitive impairment
Grafted animals showed improved spatial memory and contextual fear conditioning versus irradiated sham-surgery controls, with the best performance when grafting was delayed to 4 weeks after irradiation. Grafted cells migrated through CA1 and CA3 and differentiated into neuronal (about 39%) and astr…
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