PRECLINICAL PUBLICATION · 2014

Hyaluronan tetrasaccharide exerts neuroprotective effect and promotes functional recovery after acute spinal cord injury in rats.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Hyaluronan tetrasaccharide (HA4)

PMID 25373446 ↗2014Reported benefit

Hyaluronan tetrasaccharide exerts neuroprotective effect and promotes functional recovery after acute spinal cord injury in rats.

RatSpinal cord injuryUnspecifiedSprague-Dawley

Model: Acute spinal cord injury in rats (model details not stated in the abstract)

Hyaluronan tetrasaccharide improved locomotor and electrophysiological recovery after spinal cord injury and upregulated BDNF, VEGF, CD44 and TLR-4, with effects apparently mediated through CD44 and TLR-4.

Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.