Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation.
MouseOtherC57BL/6; soluble guanylyl cyclase alpha1 knockoutMalePrior administration for prevention; therapeutic administration 24 h after resi…
Model: Inspiratory resistive breathing produced by tracheal banding restricting tracheal surface area to 50% for 24 h
Soluble guanylyl cyclase activation with BAY 58-2667 prevented and, when given 24 h after resistive breathing, reversed the established lung injury, whereas sGC inhibition or sGC alpha1 deficiency exacerbated it.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.