Candesartan attenuates ischemic brain edema and protects the blood-brain barrier integrity from ischemia/reperfusion injury in rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMalen = Three main groups with 32 rats per group; experiments perfo…Intravenous0.1 mg/kg (non-hypotensive dose)One hour before induction of ischaemia
Model: Transient focal cerebral ischaemia by intraluminal middle cerebral artery occlusion with a 3-0 nylon filament for 60 min followed by 24 h reperfusion
A single non-hypotensive intravenous dose of candesartan one hour before middle cerebral artery occlusion improved neurological scores and reduced infarct volume by 54.9 per cent, oedema by 59.2 per cent and Evans blue extravasation by 54.9 per cent without altering arterial blood pressure.
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