Adenovector-mediated gene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats.
RatChemical/toxinSprague-DawleyMaleEndobronchial administrationOne week before intravenous oleic acid
Model: Acute lung injury induced by intravenous injection of oleic acid, with lungs examined 4 h later; in vitro hydrogen peroxide exposure of isolated alveolar type II cells
Endobronchial delivery of an LPCAT1 transgene lowered lysophosphatidylcholine content, reduced lung oedema and alveolar type II cell apoptosis, improved lung compliance and attenuated histological oleic acid-induced lung injury compared with Ad-lacZ.
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