Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing.
MouseWoundC57BLKS/J background, homozygous (diabetic) or heterozygous (non-diabetic littermate) for the spontaneous leptin receptor mutationMalen = At day 18, n=14 SA3N-treated and n=17 vehicle-treated anima…Topical injection under the Tegaderm for the first four treatments, then subcutaneous injection around the wound from day 12Reported in the full text as 35 ng per unit volume diluted…Immediately after wounding
Model: Full-thickness excisional dorsal skin wound in genetically induced type II diabetic mice, 10 mm punch biopsy outline with full-thickness excision including the panniculus carnosus, covered with Tegaderm
Serpina3n accelerated diabetic wound closure from day 12 onwards with greater re-epithelialisation and contraction, more mature granulation tissue, increased proliferation, vascularisation, myofibroblast content and collagen deposition, and preserved full-length fibronectin.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.