Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.
MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6MaleOral (dietary)Dietary intervention given before induction of intestinal ischaemia/reperfusion
Model: Intestinal ischaemia/reperfusion in mice fed isocaloric experimental diets
A diet high in n-6 PUFA reduced intestinal inflammation after ischaemia/reperfusion and raised post-ischaemic lipoxin A4 levels relative to control diet. A high n-3 diet gave no change in inflammatory profile. Blockade of the lipoxin A4 receptor Fpr2 abolished the protection.
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