Betulinic acid negates oxidative lung injury in surgical sepsis model.
MouseOtherMalen = Five groups of six mice (n = 6 per group, 30 total)3, 10 and 30 mg/kgPretreatment before injury, with the last dose 1 h before caecal ligation and p…
Model: Caecal ligation and puncture surgical sepsis with secondary oxidative acute lung injury
Caecal ligation and puncture raised oxidant markers and lowered antioxidant defences in lung and plasma with histopathological injury. Betulinic acid pretreatment restored these measures and reduced oxidative lung injury.
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