Cystathionine-gamma-lyase inhibitor attenuates acute lung injury induced by acute pancreatitis in rats.
RatOtherSprague-DawleyMalen = 54 rats, 18 per group across three groupsIntraperitoneal injection
Model: Acute pancreatitis induced by injection of 3% sodium deoxycholate at 0.1 mL per 100 g body weight at 0.2 mL/min, with secondary acute pancreatitis-associated lung injury
Acute pancreatitis raised serum hydrogen sulfide (37.97 +/- 1.56 versus 23.79 +/- 1.81 micromol/L at 6 h) and lung cystathionine-gamma-lyase and tumour necrosis factor-alpha mRNA at 3 and 6 h. Propargylglycine lowered serum hydrogen sulfide, reduced cystathionine-gamma-lyase mRNA at 3 and 6 h and t…
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