Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes.
MouseWound
Model: Excisional skin wound in diabetic mice, with macrophage depletion and transfer of macrophages isolated from diabetic mice
Injury induced endogenous NPD1 biosynthesis in wounds but diabetes impeded its formation; NPD1 was produced mainly by macrophages. NPD1, and NPD1-modulated diabetic macrophages, enhanced wound healing and innervation in diabetic mice, attenuating macrophage inflammatory activity, chronic inflammati…
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