Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response.

Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response.

Model: Cutaneous wound with subsequent skin fibrosis

Local miR-155 antagomir injection reduced immune cell recruitment, lowered IL-1beta and TNF-alpha and raised IL-10, and reduced alpha-SMA, Col1 and Col3 at both mRNA and protein level. Collagen fibres were more regularly arranged, indicating reduced fibrosis, while the rate of wound healing did not…

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