Sodium thiosulfate attenuates acute lung injury in mice.
MouseEndotoxin/LPSC57BL/6J (Jackson Laboratories)Malen = Lipopolysaccharide model: control n=8, lipopolysaccharide n…Intraperitoneal (lipopolysaccharide model); intravenous via tail vein (cecal ligation and puncture model)2 g/kg intraperitoneally in the lipopolysaccharide model; 0…At 0 and 12 h after intratracheal lipopolysaccharide; 10 min after cecal ligati…
Model: Acute lung injury induced by intratracheal lipopolysaccharide (2 mg/kg, O111:B4, in 50 microlitres saline by microsprayer) and, separately, polymicrobial sepsis by cecal ligation and puncture (cecum ligated 1.0 cm from tip, punctured twice with an 18-gauge needle)
Sodium thiosulfate reduced bronchoalveolar lavage cell and neutrophil influx, myeloperoxidase, protein leak, lung wet/dry ratio and histological injury score after intratracheal lipopolysaccharide, and cut bronchoalveolar lavage IL-6 from 313 plus or minus 164 to 79 plus or minus 27 pg/ml and TNF-a…
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