Pleiotrophin mediates hematopoietic regeneration via activation of RAS.
MouseRadiationSystemic administration, route not specified in the abstractAfter irradiation and after myeloablative bone marrow transplantation
Model: Ionizing radiation exposure causing haematopoietic toxicity, and myeloablative bone marrow transplantation
Systemic pleiotrophin substantially increased survival after radiation exposure and after myeloablative bone marrow transplantation, accelerating recovery of bone marrow haematopoietic stem and progenitor cells. Pleiotrophin induced haematopoietic stem cell quiescence and activated RAS in PTPRZ-exp…
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