Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.
MouseIschaemia-reperfusionCardiacC57BL/6; CD44 knockout mice used as a source of cultured cardiac fibroblastsMale
Model: Acute myocardial infarction in mice, with parallel in vitro studies on cultured cardiac fibroblasts
Endogenous IL-6 rapidly but transiently increased HAS1 and HAS2 expression and produced a hyaluronan-rich matrix acutely after acute myocardial infarction. Blocking IL-6 in vivo decreased hyaluronan matrix formation in the peri-infarct region, reduced alpha-smooth muscle actin-positive myofibroblas…
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