The functional study of human umbilical cord mesenchymal stem cells harbouring angiotensin-converting enzyme 2 in rat acute lung ischemia-reperfusion injury model.
RatIschaemia-reperfusionOther / unspecifiedFemalen = 50 rats randomised into five groups
Model: Acute lung ischaemia-reperfusion injury
HUMSCs-ACE2 produced lighter lung injury than either HUMSCs or ACE2 alone, with higher CD31 and von Willebrand factor expression, lower gamma-H2AX and CD68, and higher antioxidant expression (glutathione reductase, glutathione peroxidase, NQO1), indicating synergistic protection against acute lung…
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