Effects of bladder function by early tamsulosin treatment in a spinal cord injury rat model.
RatSpinal cord injuryComplete transectionSprague DawleyFemalen = 45 rats total: control n=12, spinal cord injury n=12, spina…Intraperitoneal0.1 mg/kgEarly treatment beginning after spinal cord transection, continued for 7 days
Model: Complete spinal cord transection at T10 vertebral level
Tamsulosin significantly reduced acetylcholine-induced detrusor contractility relative to untreated spinal cord injury, including after 4-DAMP pretreatment, and normalised protein expression with higher pERK1/2 and lower rho-kinase. However, awake cystometry showed no significant difference between…
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