Comparing the effects of acute alcohol consumption in germ-free and conventional mice: the role of the gut microbiota.
MouseChemical/toxinNIH Swiss (germ-free and conventional)Femalen = Groups of 5-7 animals per groupOral (dietary)AIN93 diet modified with 10 per cent pectin-soluble fibreStarted 14 days before ethanol administration
Model: Acute alcohol-induced liver injury: 10 per cent vol/vol ethanol in drinking water for 7 days with a higher oral gavage dose of alcohol on day 7
A high-fibre diet decreased intestinal permeability after excessive alcohol intake, restored small intestinal IL-1beta levels that had fallen sharply in the low-fibre ethanol group, and reduced hepatic lipid microvacuole density on histology compared with low-fibre ethanol-fed mice. Germ-free mice…
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