Renal denervation prevents long-term sequelae of ischemic renal injury.
MouseIschaemia-reperfusionRenal129S1/SvImJMaleSurgical renal denervation of the kidneyAt the time of injury, or as postconditioning up to 1 day post-injury
Model: Unilateral renal ischaemia/reperfusion injury, with contralateral nephrectomy used for glomerular filtration rate measurement; outcomes assessed 1 to 16 days post-injury
Renal denervation at the time of injury or up to 1 day afterwards markedly reduced collagen deposition, profibrotic protein expression, neutrophil and macrophage influx, tubular injury score, apoptosis, oxidative stress and G2/M cell cycle arrest from 4 to 16 days after ischaemia/reperfusion, prese…
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