Decreased GFAP expression and improved functional recovery in contused spinal cord of rats following valproic acid therapy.
RatSpinal cord injuryContusionIntraperitoneal150, 200, 300, 400 or 500 mg/kg; optimal effect at 300 mg/kg2, 6, 12 or 24 h post-injury; optimal at 12 h post-injury
Model: Spinal cord contusion injury, with outcomes followed for 12 weeks and tissue analysed 3 months post-injury
Valproic acid-treated contused rats showed significantly greater reductions in cavitation, H/M ratio and GFAP expression and higher Basso-Beattie-Bresnahan scores than untreated animals (P < 0.05). The optimal regimen was 300 mg/kg given 12 h after injury, which produced the greatest increase in lo…
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