Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice.
MouseSpinal cord injuryContusionC57BL/6Femalen = Systemic study 12 mice per treatment group; central study g…Central intrathecal infusion to the lesion epicentre (osmotic pump) or systemic subcutaneous injectionCentral: XPro1595 2.5 mg/mL delivered at 1 microlitre per h…First administration 30 minutes after spinal cord injury
Model: Moderate contusion spinal cord injury at T8 to T10 by impactor after laminectomy
Systemic subcutaneous XPro1595 or etanercept produced no discernible improvement in locomotor recovery. Central infusion of XPro1595 improved locomotor function, reduced anxiety-related behaviour and reduced tissue damage with preserved myelin basic protein, whereas central etanercept had no therap…
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