Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.
MouseRadiationAthymic nudeIntraperitonealSchedules included dosing before irradiation and a post-irradiation only schedu…
Model: Single large dose of ionising radiation delivered to a 4 square centimetre area of flank skin (30 or 40 Gy)
Vasculotide reduced the size of the irradiation-induced wound and overall skin damage, lowered oxygenated haemoglobin, myeloperoxidase bioluminescence and MIP-2, increased microvascular endothelial cell density in granulation tissue and enhanced endothelial survival and function in vitro, without a…
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