Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury.
MixedTBIUnspecifiedSprague-Dawley rats; C57BL/6 mice including osteopontin knockout miceMaleAdministered after injury during the first week postinjury
Model: Unilateral entorhinal cortex lesion producing hippocampal deafferentation and reactive synaptogenesis
Osteopontin protein and transcript rose more than 50-fold in activated glia at 1 to 2 days after lesion. Minocycline attenuated MMP-9 activity, reduced LCN2 expression and osteopontin fragment generation, and attenuated removal of synapsin-1 positive axons from the deafferented zone. Osteopontin kn…
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