Bone morphogenetic protein 4 inhibits liposaccharide-induced inflammation in the airway.
MixedEndotoxin/LPSC57BL/6 background; BMP4 mutant (BMP4+/-) mice compared with BMP4+/+ littermates
Model: Lipopolysaccharide (LPS)-induced acute airway inflammation, chronic LPS exposure, and Pseudomonas aeruginosa lung infection; LPS or TNF-alpha stimulation of airway epithelial cells and peritoneal macrophages in vitro
BMP4 was upregulated in LPS-inflamed lungs and in airway epithelial cells treated with LPS or TNF-alpha. BMP4+/- mice showed more severe lung inflammation and lower bacterial load after LPS or Pseudomonas aeruginosa than BMP4+/+ mice, and BMP4 knockdown increased LPS and TNF-alpha induced IL-8 in 1…
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