Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain.
MixedOtherICR mice; Sprague-Dawley ratsMalen = 6 animals per group in the behavioural tests; 30 SNI rats r…Intraperitoneal25 and 100 µg/kg in the acetic acid abdominal constriction…15 min before acetic acid injection; before intraplantar formalin (Methods stat…
Model: Acetic acid (0.8%, 0.2 mL i.p.) induced abdominal constriction in mice; 5% formalin (50 µL) intraplantar injection into the hind paw in rats; spared nerve injury (SNI) with ligation and transection of the sural, common peroneal and tibial branches of the sciatic nerve in rats; rotarod test for motor side effects
Dose-dependent analgesia across three models. In the acetic acid writhing test the peptide reduced pain responses by 25.2% (P<0.05) at 25 µg/kg and 55.6% (P<0.01) at 100 µg/kg, comparable with 58.3% (P<0.01) for morphine 50 µg/kg. In the rat formalin test the late-phase 40 min pain score fell from…
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