Interleukin-1β induces autophagy by affecting calcium homeostasis and trypsinogen activation in pancreatic acinar cells.
MixedChemical/toxinC57BL/6MaleCo-treatment with cerulein in vivo; exact timing not stated
Model: Cerulein-induced acute pancreatitis in mice; IL-1beta stimulation of AR42J pancreatic acinar cells in vitro
IL-1beta triggered autophagy with impaired autophagic flux in AR42J cells, induced calcium release from the endoplasmic reticulum and increased the ER stress markers GRP78 and IRE1, and induced trypsinogen activation to trypsin with reduced acinar cell viability. 2APB, an InsP3 receptor antagonist,…
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