Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord.
RatOtherSprague-DawleyMaleIntrathecal
Model: Spared nerve injury neuropathic pain model involving sural nerve transection, with sham-operated controls
Sural nerve transection lowered the threshold for C-reflex activation and produced persistent mechanical hypersensitivity to pressure stimuli. Intrathecal administration of the three pannexin 1 blockers significantly depressed spinal C-reflex wind-up activity in both neuropathic and sham rats, and…
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