Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalen = 67 male rats in total. Experiment 1: sham n = 10, hypoxia-i…Intraperitoneal injection30 mg/kgFirst dose after recovery from carotid artery cauterisation and immediately bef…
Model: Neonatal hypoxic-ischaemic brain injury on postnatal day 7 by complete cauterisation of the right common carotid artery followed, after 2 to 3 h of recovery with the dam, by humidified 8% oxygen and 92% nitrogen for 90 minutes (experiment 1) or 120 minutes (experiment 2)
IAIP treatment significantly reduced Fluoro-Jade B positive cells in the ipsilateral cerebral cortex 72 h after hypoxia-ischaemia compared with vehicle-treated injured rats (p = 0.023, one tailed), with labelling similar to shams, and prevented the hypoxic-ischaemic reduction in brain weight. In ad…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.