Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMale0.9 ml/kg (DHI-L) and 1.8 ml/kg (DHI-H)
Model: Cerebral ischaemia/reperfusion injury induced by middle cerebral artery occlusion; in vitro model of H2O2-wounded mouse Neuro-2A cells
Danhong injection ameliorated neurological score, cerebral infarction and brain oedema, increased SOD and GSH, decreased MDA, and upregulated Nrf2, HO-1 and NQO1 expression in ischaemic brain tissue in vivo. In vitro it increased Nrf2 and HO-1 mRNA transcription and upregulated Nrf2 protein. The au…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.