Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration.
MouseRadiationBALB/c (albino)n = n = 8 to 12 eyes per group for electroretinography; at leas…Intravitreal (trans-scleral) injection2 microlitres of 0.1, 1.0 or 5.0 micromolar nanoparticle su…Pre-treatment 13 to 15 days before light exposure, or immediately (2 h) after l…
Model: Light damage model: 48 h dark adaptation followed by 2 h exposure to 8,000 lux constant bright light
Pre-treatment at 0.1 to 5.0 micromolar preserved scotopic and photopic ERG amplitudes and outer nuclear layer structure, with complete functional protection at 5.0 micromolar. Post-treatment was effective only at 1.0 micromolar and gave a smaller benefit. Nanoparticles alone caused no retinal toxic…
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