Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = 40 rats: injury plus valproic acid n = 8, injury plus vehic…Intravenous bolus300 mg/kg30 minutes after injury
Model: Severe controlled cortical impact, isolated traumatic brain injury, animals killed 6 h after injury
Traumatic brain injury increased serum syndecan-1 at 3 and 6 h. Valproic acid reduced lesion size (40.45 mm versus 59.57 mm, p = 0.023) but was associated with greater glycocalyx shedding at 3 h, and syndecan-1 correlated inversely with lesion size.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.