Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.
MouseRadiationC57BL/6 (donor C57BL/6-Ly-5.1, recipient C57BL/6-Ly-5.2)Malen = Seven recipient mice per group in competitive repopulation…In vitro incubation of bone marrow mononuclear cells0.01 to 100 micromolar for viability assays; 0.01 to 1 micr…Incubation for 60 minutes before irradiation
Model: Ex vivo gamma irradiation of bone marrow mononuclear cells at 1, 2 or 4 Gy at 0.76 Gy/min; recipients received 9.0 Gy total body irradiation before transplantation
Heyneanol-A, isorhapontigenin and resveratrol improved viability of irradiated bone marrow mononuclear cells and CFU-GM colony formation. Heyneanol-A and resveratrol also enhanced long-term multilineage engraftment, increasing donor engraftment by 13.07% and 11.58% respectively at 2 months, whereas…
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