Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.
MixedIschaemia-reperfusionOther / unspecifiedMG53-knockout and wild-type mice; Sprague-Dawley and Wistar ratsMale and femaleIntravenous delivery or inhalation
Model: Ischaemia-reperfusion and overventilation-induced acute lung injury, emphysema and chronic lung injury models, with anoxia and reoxygenation in cultured lung epithelial cells
MG53-deficient mice were more susceptible to ischaemia-reperfusion and overventilation lung injury. Extracellular recombinant human MG53 protected cultured lung epithelial cells and, given intravenously or by inhalation, reduced injury in rodent models of acute lung injury and emphysema, with repea…
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