PRECLINICAL PUBLICATION · 2014

Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model.

Mouse / Burn

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Soluble DR5 (recombinant decoy receptor)

PMID 25031778 ↗2014Reported benefit

Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model.

MouseBurnScaldC57BL/6Male

Model: Full thickness scald burn, kidney assessed 24 h after burn

Renal apoptosis and TRAIL and DR5 expression increased 24 h after full thickness scald burn. Soluble DR5 reduced apoptotic cell death and alleviated burn-induced acute kidney injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.