Ozone therapy ameliorates paraquat-induced lung injury in rats.
RatChemical/toxinSprague-DawleyFemalen = n = 24 rats across three groupsIntraperitoneal1 mg/kg/day ozone-oxygen mixtureFirst dose 1 h after paraquat administration
Model: Paraquat 15 mg/kg intraperitoneally to induce acute lung injury, animals killed on day 5
Ozone therapy significantly lowered serum lactate dehydrogenase and neopterin, tissue oxidative stress parameters, TGF-beta1 and histological injury scores, and raised total antioxidant capacity compared with paraquat alone.
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