Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice.
MouseEndotoxin/LPS1 h after lipopolysaccharide injection
Model: Acute kidney injury induced by intraperitoneal lipopolysaccharide 35 mg/kg
Lipopolysaccharide raised plasma urea and renal lipopolysaccharide-binding protein, CD14, TNF-alpha and IL-6 without clear changes in mitogen-activated protein kinases. Normal mesenteric lymph reduced urea, CD14, TNF-alpha and IL-6, consistent with attenuated lipopolysaccharide sensitisation.
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