PRECLINICAL PUBLICATION · 2014

Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage.

Rat / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

DSM-RX78 and EFB-1 (phosphodiesterase 4 inhibitors) in nanostructured lipid carriers, with and without polyethylene glycol surface coating

PMID 25016652 ↗2014Reported benefit

Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage.

RatHaemorrhage/shockUnspecifiedSprague-DawleyMaleSystemic nanoparticle delivery

Model: Traumatic haemorrhage (haemorrhagic shock) model in rats

Nanostructured lipid carriers gave sustained release with lower plasma concentrations and shorter half-lives, and high accumulation in brain and lungs. Polyethylene glycol coating reduced brain delivery and increased lung distribution five-fold compared with free drug, and EFB-1 in coated carriers…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.