The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model.
MouseWoundFemaleSubcutaneous or intraperitoneal osmotic pump8.7 x 10^3 units/hFrom the time of wounding
Model: Full-thickness skin necrosis produced by argon laser radiation
Gamma interferon reduced fibrous tissue and collagen in healing scars at 14 and 21 days, increased hyaluronate-rich acid mucopolysaccharide, and delayed full skin closure by 23 to 27 per cent, while reducing perilesional erythema and early neutrophil infiltration.
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