Simvastatin combined with antioxidant attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
RatTBIWeight-drop / impact-accelerationSprague-DawleyMalen = 30 rats total, 6 per group across 5 groupsOral, via orogastric tubeSimvastatin 15 mg/kg per day in 1 mL distilled water; vitam…First dose 1 h after injury
Model: Cortical contusion by weight-drop, 20 g brass weight from 40 cm onto a footplate over the left hind paw sensorimotor cortex, 10 repeated impacts
All treatment groups reduced serum ICAM-1 relative to untreated TBI, with the combination significantly lower than the statin-alone group at 24 h and lower than control at 24 h and day 7. No IL-10 effect was detected. All treated groups outperformed controls on grip testing at 24 h, 72 h and 7 days…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.