alpha-conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement.
RatOtherSprague-DawleyMalen = 12 rats per group for behaviour (2 experimental sets); 6 ra…Intramuscular, into the ipsilateral paw muscle2 nmol or 10 nmol in 100 microlitres sterile salineFirst dose 60 min after surgery, after recovery from anaesthesia
Model: Chronic constriction injury (CCI) of the right sciatic nerve, four loose chromic gut ligatures at 1 mm spacing
Fourteen days of RgIA prevented hypersensitivity: paw pressure threshold rose to 61.7 plus or minus 0.6 g (2 nmol) and 65.0 plus or minus 0.9 g (10 nmol) versus 39.2 plus or minus 1.3 g for CCI plus vehicle, with von Frey thresholds also preserved and postural imbalance relieved by 62% and 74% resp…
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