Ouabain improves functional recovery following traumatic brain injury.
MouseTBIWeight-drop / impact-accelerationMaleIntraperitoneal1 microgram/kgChronic dosing regimen after closed head injury; acute single administration wa…
Model: Closed head injury (CHI) weight-drop model of traumatic brain injury
Chronic but not acute low-dose ouabain significantly improved recovery and functional outcome, reduced lesion size at 43 days and increased proliferating cells in the subventricular zone and around the injury site. Neuronal proliferation almost doubled versus vehicle while endothelial and astrocyte…
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