Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration.
RatChemical/toxinSprague-Dawleymalen = 6-8 animals per group; seizure screening used 10 rats per g…intraperitoneal30 mg/kg and 40 mg/kg40 min before kainic acid injection
Model: Intracerebroventricular kainic acid (100 ng/uL in 0.01 M PBS, 6.5 uL) stereotaxically injected into the left lateral ventricle under pentobarbital sodium anaesthesia (50 mg/kg i.p.)
Both 30 and 40 mg/kg reduced acute (48 h) Fluoro-Jade C damage scores in CA1 and CA3 (p<0.05 to p<0.001) and preserved GAD67-positive and parvalbumin-positive interneurons (p<0.01 to p<0.001). Both doses restored Morris water maze escape latencies to saline-control levels, and 30 mg/kg significantl…
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