Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-Dawleyn = 48 rats total, 16 per group; 8 per group for biochemistry a…Intraperitoneal2 mg/kg body weight (methylprednisolone comparator 30 mg/kg…First dose 30 min after injury
Model: Acute spinal cord injury by Allen's weight-drop method, 7 g x 3 cm extradural impact at spinal segment T11
Both meglumine cyclic adenylate and methylprednisolone groups showed higher cAMP concentrations and adenylate cyclase 3 activity, lower phosphodiesterase 4D activity at the lesion site and better behavioural scores than saline controls (P<0.05). cAMP was higher with meglumine cyclic adenylate than…
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