N-terminal truncations of substance P 1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats.
RatSpinal cord injuryUnspecifiedSprague-Dawleyfemaleintraperitoneal
Model: Experimental spinal cord injury producing chronic central neuropathic pain with mechanical allodynia
Most of the compounds tested alleviated mechanical allodynia without signs of sedation or motor impairment. The response threshold to acute nociceptive stimulation was not affected by any compound. Most amino acids in the heptapeptide structure were required for biological effect after peripheral i…
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