4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration.
RatChemical/toxinSprague-Dawleymalen = Experiment 1 n=11 rats per group; experiment 2 n=8 versus n…subcutaneous (interscapular)6 mg/kg in DMSO, injection volume 1 mL/kg1 h before DFP, or 5 h or 24 h after DFP
Model: Acute organophosphate poisoning with diisopropylfluorophosphate (DFP) 9 mg/kg dissolved in cold water and injected intraperitoneally; mortality reduced by peripherally acting intramuscular pretreatment with pyridostigmine bromide 0.1 mg/kg, ipratropium bromide 23 mg/kg and methyl atropine nitrate 20 mg/kg
DFP reduced acetylcholinesterase activity to less than 10% of control in all brain areas 15 min after injection. 4R-cembranoid was not anticonvulsant (total convulsions 323 +/- 26 with 4R pretreatment versus 388 +/- 26 for DFP alone, not significant). At 48 h, 4R given 1 h before DFP significantly…
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