PRECLINICAL PUBLICATION · 2014

Platelet factor 4 protects bone marrow mesenchymal stem cells from acute radiation injury.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Platelet factor 4 (PF4/CXCL4)

PMID 24922360 ↗2014Reported benefit

Platelet factor 4 protects bone marrow mesenchymal stem cells from acute radiation injury.

MouseRadiationC57BL/6Male

Model: Gamma-irradiation of bone marrow mesenchymal stem cells at 500 cGy, studied ex vivo and in vitro

Platelet factor 4 produced dose- and time-dependent increases in cell viability and survival with reduced apoptosis, S phase arrest, increased Bcl-2 and loss of p53/p21.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.