Dehydroepiandrosterone modulates the inflammatory response in a bilateral femoral shaft fracture model.
MouseFractureFemurC57/BL6Malen = 54 mice in total, 18 per group with 6 per time pointSubcutaneous injection into the nuchal fold25 mg/kg per 24 h, dissolved in 70% ethanol and diluted in…Directly after the fracture or sham operation
Model: Closed bilateral femoral shaft fracture produced with a standardised blunt guillotine device followed by retrograde intramedullary nailing with a 27G needle
DHEA lowered the systemic inflammatory response at 6 h, with IL-6 322.2 versus 62.5 pg/ml (p=0.01), IL-1 beta 1422.6 versus 754.1 pg/ml (p=0.05) and MCP-1 219.4 versus 44.1 pg/ml. KC, IL-10 and pulmonary inflammation were unchanged.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.